subject: Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses
object_opposite: Release of viral particles one at a time, Old paradigm:A central paradigm within virology is that each viral particle largely behaves as an independent infectious unit. Here, we demonstrate that clusters of enteroviral particles are packaged within phosphatidylserine (PS) lipid-enriched vesicles that are non-lytically released from cells and provide greater infection efficiency than free single viral particles. We show that vesicular PS lipids are co-factors to the relevant enterovirus receptors in mediating subsequent infectivity and transmission, in particular to primary human macrophages. We demonstrate that clustered packaging of viral particles within vesicles enables multiple viral RNA genomes to be collectively transferred into single cells.
misc: Clusters of viruses are packaged and released non-lytically in PS lipid vesicles PS lipids are co-factors in mediating subsequent infectivity and transmission PS vesicles provide greater infection efficiency for viruses PS vesicles enable viral genome clusters to be transmitted en bloc cell-to-cell
author_year: Ying-Han Chen/WenLi Du/Marne C. Hagemeijer/Peter M. Takvorian/Cyrilla Pau/Ann Cali/Christine A. Brantner /Erin S. Stempinski/Patricia S. Connelly/Hsin-Chieh Ma/Ping Jiang/Eckard Wimmer/Grégoire Altan-Bonnet/Nihal Altan-Bonnet /12 February 2015
journal_volume_page: Cell/Volume 160/Issue 4/p619–630
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