MORE ON GLDH INSULIN CONNECTION AND ITS CONTROLS

subject: Glutamate Dehydrogenase= GLDH. Involved in NH3+ production as well as alpha keto glutarate. Activated by ATP ( increased ATP/ADP ratio ), valine. ADP, Leucine, isoleucine, ALLOSTERIC CONTROL. PRODUCES NADH, ATP. HELPS TO PRODUCE INSULIN RELEASE ESPECIALLY IN FACE OF HYPOGLYCEMIA. iNCREASED GLUCOSE MEANS DECREASED GLDH ACTIVITY.VIA LEUCINE/GLUTAMATE CONTROL OF GLDH
object_opposite: Allosteric control ie inhibition - GTP GDP Palmitoyl Coa, ZN+2 ADP DIMINISHES. SEE http://bit.ly/1zfltmm
misc: Involved in Glucose (insulin metabolism) and TCA Cycle (isoleucine) as well as urea cycles (alpha keto glutarate) oxalo acid).The control of GDH through ADP-ribosylation is particularly important in insulin-producing β cells. Beta cells secrete insulin in response to an increase in the ATP:ADP ratio, and, as amino acids are broken down by GDH into α-ketoglutarate, this ratio rises and more insulin is secreted. SIRT4 is necessary to regulate the metabolism of amino acids as a method of controlling insulin secretion and regulating blood glucose levels. bit.ly/1zst5GZ
author_year: Public - updated daily bit.ly/1yTot9c
journal_volume_page: Wikipedia see link

subject: TRANSCIPTION ENHANCED BY HISTONE ACETLYTRANSFERASE (HAT) ACETLAATION = IMPORTANT FUNCTION IN THIS CATEGORY
object_opposite: nOTE HISTONE DEACYTYLASE (hdac) IS AN ANTITRANSCRIPTION OR DOWNREGULATOR OF TRANSCRIPTION- LESS ACCESSIBLE DNA ESSENTIAL NOTION OF DEACETLAATION
misc: SEE TRANSCIPTION FACTORS WIKIPEDIA http://bit.ly/1CFPHq2
author_year: PUBLIC
journal_volume_page: WIKIPEDIA