subject: BCKDH involved in the metabolism of leucine.Insulin release is stimulated by Glucose in high levels. Leucine and Alanine also work on Increasinag Insulin release by Increasing activity of BCKDH in the presence of GLUTAMINE. Glutamine is metabolized to Glutamate (not a secretagogue) via its DEAMINATION Glutamate Dehydrgenase. Glucose diminishes the leucine activity by diminshing the BCKDH enzymes' production(dec. the mRNA)
object_opposite: BCKDH = Branched Chain Dehydrogenase. Hyperinsulinemia, which potentially could result from the combined glucose and leucine/glutamine insulin release. Malate is not a secretagouge. Alanine is
misc: bit.ly/1AF2yIr University of Wisconsin
author_year: Micheal MacDonald/91 Deborah McKenie
journal_volume_page: Journal of Biologic Chemistry(266)/1335-40
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