Wednesday, January 14, 2015

Diminish XIa and live . At least you will be less likely to throw an embolus .

I like Andrews breakdown of clotting and his renaming



Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

Harry R. Büller, M.D., Claudette Bethune, Ph.D., Sanjay Bhanot, M.D., Ph.D., David Gailani, M.D., Brett P. Monia, Ph.D., Gary E. Raskob, Ph.D., Annelise Segers, M.D., Peter Verhamme, M.D., and Jeffrey I. Weitz, M.D. for the FXI-ASO TKA Investigators
N Engl J Med 2015; 372:232-240January 15, 2015DOI: 10.1056/NEJMoa1405760

From the discussion

reducing factor XI levels in patients undergoing elective primary unilateral total knee arthroplasty was an effective method for its prevention and appeared to be safe with respect to the risk of bleeding.

In the beginning

 Too much time between posts. Please excuse me. When not working, volunteering playing and singing , Gospel piano/Math tutor, practicing sax, flute, harmonica, and piano, as well as attempting to master Cakewalk and reading up on Herbal medicine, I have little time for nonsense. Yet nonsense is what I find myself doing in pursuing wordly goals of conquest as well as a desire to be confirmed by it.
   I have been  distracted from my true purpose at this stage of my life.This purpose is to prove up my MODEL OF INFLAMMATION (MOI )as it relates to its articulation  with the heretofore preexisting and proven TCA, UREA CYCLES and CHAINS of GLYCOLYSIS, CLOTTING, RESPIRATION, and PROSTAGLANDINS.    
  Today I got up at 3:30 am to break back into the good habit of attempting to prove up each step. The MOI has been on my mind but I had not made steps to prove it up being distracted by the cares of this world. The cares strangulated the vision . While pouting about not having my software to assimilate a torrent of data, I have been frozen with inactivity similar to a catatonic schizophrenic- doing nothing in the way of research. I realize that there is a conspiracy of silence with respect to the researching medical community interested in proving THEMSELVES up for their grants. The last thing they want to admit is shielding information from the public which may be of some general value. Would the public respond and  read and or listen> Are they being strangulated by worldly pursuits?
   The first of  nearly 120 steps have been proven up. I realized that most of the work has been done and all has fallen in place with no credit belonging to me for the original concept or the work put in. Only through the grace of God have I the resources to complete the good work started. By grace of God I mean needing  to become hermit-like as opposed to seeking confirmation from the world.. Withdrawing  from the world is what any good writer should do and does do n'est pas ?
    If I may, the study today was of Interleukin One (IL1) as well as its relationship to NF-kB. as well and its subunits / IL10 feedback as well as their relationship to DM, skin disease. and liver disease. In addition I discovered the relationship of IL1  to pathophysiology of hepatic disease. In essence it is related to the unabated blockage of NF-kB in the presence of normal TNF-alpha concentrations. Apoptosis of  the liver occurs. Metalloproteinases and their importance to disease were also uncovered.
    So in essence we are going to reverse this thing. Less time on reading meaningless Facebook posts. Less time in looking at old pics and posting them. Less time in self promotion. Less time out of my lane. More time spent on helping to actualize a dream of an all-encompassing proposal and model of all fatalities of disease being related to inflammation and/or  its resultant ischemia/ hypovolemia as well as relationship to the aforementioned.
    Between cytokines, their receptors and the consequences of cytopathic as well as pathophysiologic aberrancy, I am able to understand a little more. Just a few suggestions toward those who advocate longevity:
1. Get more exercise- I am swimming and lifting weights. Circulation is everything for the natural neuro-humoral-immunologic system to readjust itself.   2. Drink more fluids 3. Take huge dose of vitamin  C  1500 mg/day will keep your enzymes reduced. 4. Eat a salad before each meal and drink more soup prior to eating. 5. Practice loving yourself with good thoughts toward yourself, toward your God (hopefully it is not cathexic toward others and or self) and your neighbor. This will maintain the peace in your community and IN YOU.

Diminishing Factor XIa diminishes venous thromboembolism post Knee surgery.

reducing factor XIa levels in patients undergoing elective primary unilateral total knee arthroplasty was an effective method for its prevention and appeared to be safe with respect to the risk of bleeding."diminishing Factor Xi