Diminish XIa and live . At least you will be less likely to throw an embolus .

I like Andrews breakdown of clotting and his renaming

Andrew's explanation

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

Harry R. Büller, M.D., Claudette Bethune, Ph.D., Sanjay Bhanot, M.D., Ph.D., David Gailani, M.D., Brett P. Monia, Ph.D., Gary E. Raskob, Ph.D., Annelise Segers, M.D., Peter Verhamme, M.D., and Jeffrey I. Weitz, M.D. for the FXI-ASO TKA Investigators

N Engl J Med 2015; 372:232-240January 15, 2015DOI: 10.1056/NEJMoa1405760

From the discussion

reducing factor XI levels in patients undergoing elective primary unilateral total knee arthroplasty was an effective method for its prevention and appeared to be safe with respect to the risk of bleeding.