subject: Treatment
with 2DG and cisplatin also caused perturbations in parameters indicative of
oxidative stress/increasing percentage of glutathione disulfide. Exposure of
FaDu cells to the combination of 2DG and cisplatin resulted in a significant
decrease in cell survival when compared with 2DG or cisplatin alone
object_opposite: decreased intracellular total glutathione An inhibitor of glutathione synthesis, l-buthionine-[S,R]-sulfoximine (BSO), sensitized FaDu cells to the cytotoxic effects of 2DG and cisplatin, and these effects were inhibited by NAC
misc: http://cancerres.aacrjournals.org/content/67/7/3364.short Article Simultaneous treatment with the thiol antioxidant N-acetylcysteine (NAC) inhibited parameters indicative of oxidative stress, as well as protected FaDu cells from the cytotoxic effects of cisplatin alone and the combination of 2DG and cisplatin
author_year: Andrean L. Simons/ Iman M. Ahmad/ David M. Mattson1/ Kenneth J. Dornfeld/ Douglas R. Spitz1/07
journal_volume_page: [Cancer Res/67/(7/3364–70]
object_opposite: decreased intracellular total glutathione An inhibitor of glutathione synthesis, l-buthionine-[S,R]-sulfoximine (BSO), sensitized FaDu cells to the cytotoxic effects of 2DG and cisplatin, and these effects were inhibited by NAC
misc: http://cancerres.aacrjournals.org/content/67/7/3364.short Article Simultaneous treatment with the thiol antioxidant N-acetylcysteine (NAC) inhibited parameters indicative of oxidative stress, as well as protected FaDu cells from the cytotoxic effects of cisplatin alone and the combination of 2DG and cisplatin
author_year: Andrean L. Simons/ Iman M. Ahmad/ David M. Mattson1/ Kenneth J. Dornfeld/ Douglas R. Spitz1/07
journal_volume_page: [Cancer Res/67/(7/3364–70]
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