AMIE /TH17 /regulatory examples

subject: chagas + extent of myocardiopathy Deficient regulatory T cell activity and low frequency of IL-17-producing T cells
object_opposite: 1L17/Deficient regulatory T cell activity and low frequency of IL-17-producing T cells
misc: Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease/Myocardium damage during Chagas' disease results from the immunological imbalance between pro- and production of anti-inflammatory cytokines and has been explained based on the Th1-Th2 dichotomy and regulatory T cell activity. Recently, we demonstrated that IL-17 produced during experimental T. cruzi infection regulates Th1 cells differentiation and parasite induced myocarditis. Here, we investigated the role of IL-17 and regulatory T cell during human Chagas' disease.
author_year: Authors: Guedes PM, /Gutierrez FR, /Silva GK, Dellalibera-Joviliano R, /Rodrigues GJ,/ Bendhack LM, Rassi A,/ Rassi A, /Schmidt A, /Maciel BC, /Marin Neto JA/
journal_volume_page: pubmed 6(4): e1630