subject: We
show that Teff and Treg require distinct metabolic programs to support these
functions. Th1, Th2, and Th17 cells expressed high surface levels of the
glucose transporter Glut1 and were highly glycolytic
object_opposite: Treg, in contrast, expressed low levels of Glut1 and had high lipid oxidation rates. Consistent with glycolysis and lipid oxidation promoting Teff and Treg, respectively, Teff were selectively increased in Glut1 transgenic mice and reliant on glucose metabolism, whereas Treg had activated AMP-activated protein kinase and were dependent on lipid oxidation. Importantly, AMP-activated protein kinase stimulation was sufficient to decrease Glut1 and increase Treg generation in an asthma model
misc: Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
author_year: Ryan D. Michalek/ Valerie A. Gerriets/ Sarah R. Jacobs/ Andrew N. Macintyre/ Nancie J. MacIver/ Emily F. Mason/ Sarah A. Sullivan/ Amanda G. Nichols/ Jeffrey C. Rathmell/2011
journal_volume_page: Journal of Immunology/10/4049
object_opposite: Treg, in contrast, expressed low levels of Glut1 and had high lipid oxidation rates. Consistent with glycolysis and lipid oxidation promoting Teff and Treg, respectively, Teff were selectively increased in Glut1 transgenic mice and reliant on glucose metabolism, whereas Treg had activated AMP-activated protein kinase and were dependent on lipid oxidation. Importantly, AMP-activated protein kinase stimulation was sufficient to decrease Glut1 and increase Treg generation in an asthma model
misc: Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
author_year: Ryan D. Michalek/ Valerie A. Gerriets/ Sarah R. Jacobs/ Andrew N. Macintyre/ Nancie J. MacIver/ Emily F. Mason/ Sarah A. Sullivan/ Amanda G. Nichols/ Jeffrey C. Rathmell/2011
journal_volume_page: Journal of Immunology/10/4049
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